Services

Services & Specialties

End-to-end engineering consulting for sterile pharmaceutical production — from initial facility concept through qualification, commissioning, and ongoing operational support.

Sterile Facility Design & Production Flows

Proper design assures functional needs and regulatory requirements. Essential for efficient operation and obtaining regulatory approvals smoothly. Covers layout, material/operator/waste flows, pressure cascades, airflows, and clean room classification.

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URS Writing & Equipment Procurement

Covering the entire field of engineering procurement — from writing specifications and User Requirement Specifications, comparing suppliers, performance of acceptance tests (FAT, SAT), to obtaining the best selection of equipment at the lowest costs.

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Production Processes & Scale-Up

Detailed planning of production processes serving as a basis for production worksheets and computerized control systems. Proper scale-up requires thorough understanding of system components and the physical parameters that characterize them.

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New Technologies & Equipment Implementation

Sterile production includes complex technologies such as bulk sterilization, homogenization, and particle size reduction. Deep knowledge of these technologies and equipment provides significant advantage in assimilation time and implementation accuracy.

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Training

Targeted training for engineering, operations, and quality teams supporting sterile manufacturing, including practical guidance and knowledge transfer.

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Support on-going Production Activities

Ongoing production support for sterile manufacturing sites, including troubleshooting, process optimization, and assistance with operational challenges.

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Sterilization Processes - Design and Validation

Design and validation support for moist and dry heat sterilization processes, including cycle development, technical review, and process assurance.

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Validation, Qualification & Compliance

Full CQV services: IQ/OQ/PQ management, protocol writing, clean room and equipment qualification, SOPs, quality policies, and regulatory compliance including 21 CFR Part 11 and Annex 1.

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Troubleshooting & Emergency Support

When a sterile production line fails, when a process is unstable, when equipment integration does not perform as expected — rapid diagnostic response to identify root causes and deliver practical, implementable solutions.

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Annex 1 & Regulatory Compliance

The updated Annex 1 is the most significant regulatory change in decades. 10AR provides deep expertise in CCS development, barrier technology guidance, PUPSIT implementation, and comprehensive gap analysis services.

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